Yi-Ching Wang Selected Research

Monomeric GTP-Binding Proteins

1/2022	Targeting protumor factor chitinase-3-like-1 secreted by Rab37 vesicles for cancer immunotherapy.
11/2018	VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.
10/2018	Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype.
1/2018	Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.
12/2017	Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37.
5/2017	Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.
9/2014	Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.
3/2009	Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer.

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Yi-Ching Wang Research Topics

Disease

74	Neoplasms (Cancer) 05/2022 - 04/2002
50	Lung Neoplasms (Lung Cancer) 05/2022 - 04/2002
18	Neoplasm Metastasis (Metastasis) 01/2019 - 02/2005
15	Carcinogenesis 11/2020 - 04/2002
13	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2017 - 07/2004
11	Esophageal Squamous Cell Carcinoma 11/2020 - 11/2005
8	Squamous Cell Carcinoma (Epidermoid Carcinoma) 09/2009 - 07/2004
7	Breast Neoplasms (Breast Cancer) 01/2019 - 08/2009
6	Adenocarcinoma of Lung 01/2022 - 02/2007
4	Adenocarcinoma 01/2022 - 04/2002
3	Esophageal Neoplasms (Esophageal Cancer) 01/2022 - 08/2012
3	Necrosis 01/2020 - 03/2004
3	Triple Negative Breast Neoplasms 01/2017 - 01/2013
3	Hepatocellular Carcinoma (Hepatoma) 02/2005 - 03/2004
2	Mouth Neoplasms (Oral Cancer) 02/2017 - 09/2015
2	Squamous Cell Neoplasms (Squamous Cell Cancer) 08/2006 - 11/2005
2	Hemorrhage 03/2004 - 03/2004
1	Dementia (Dementias) 04/2022
1	Stroke (Strokes) 03/2022
1	Malnutrition (Nutritional Deficiencies) 01/2022
1	Colonic Neoplasms (Colon Cancer) 01/2022

Drug/Important Bio-Agent (IBA)

35	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2002
19	Messenger RNA (mRNA)IBA 01/2022 - 03/2003
16	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 04/2002
14	Biomarkers (Surrogate Marker)IBA 01/2022 - 09/2006
8	Monomeric GTP-Binding ProteinsIBA 01/2022 - 03/2009
7	Pharmaceutical PreparationsIBA 01/2022 - 03/2008
7	Histone Deacetylase InhibitorsIBA 01/2017 - 09/2010
6	Histone Deacetylases (Histone Deacetylase)IBA 01/2021 - 09/2010
5	Transcription Factors (Transcription Factor)IBA 01/2022 - 09/2014
5	MethyltransferasesIBA 06/2014 - 02/2007
4	MicroRNAs (MicroRNA)IBA 01/2022 - 01/2014
4	Oncogene Proteins (Oncogene Protein)IBA 01/2019 - 08/2010
4	Indicators and Reagents (Reagents)IBA 01/2019 - 09/2010
4	PaxillinIBA 05/2017 - 01/2008
4	EnzymesIBA 01/2014 - 02/2007
4	beta CateninIBA 01/2010 - 03/2008
3	Interleukin-6 (Interleukin 6)IBA 01/2022 - 09/2015
3	CateninsIBA 01/2022 - 09/2014
3	Protein Isoforms (Isoforms)IBA 01/2022 - 10/2012
3	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2020 - 09/2009
3	Actins (F Actin)IBA 12/2015 - 09/2010
3	ChromatinIBA 02/2015 - 02/2007
3	Cisplatin (Platino)FDA LinkGeneric 04/2014 - 01/2007
3	beta-Transducin Repeat-Containing ProteinsIBA 02/2010 - 09/2009
3	ParaffinIBA 01/2010 - 05/2008
2	Estrogens (Estrogen)FDA Link 05/2022 - 01/2022
2	Estradiol (Delestrogen)FDA LinkGeneric 05/2022 - 01/2022
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2022 - 01/2013
2	benzamideIBA 01/2021 - 01/2012
2	Fibronectins (Fibronectin)IBA 11/2020 - 09/2012
2	VimentinIBA 11/2020 - 01/2011
2	Phosphotransferases (Kinase)IBA 06/2020 - 01/2010
2	Sirtuin 1IBA 02/2019 - 08/2009
2	Tissue Inhibitor of MetalloproteinasesIBA 11/2018 - 12/2017
2	Glycoproteins (Glycoprotein)IBA 12/2017 - 01/2010
2	TMU-35435IBA 01/2017 - 01/2017
2	Vorinostat FDA Link 10/2016 - 01/2013
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 06/2016 - 12/2011
2	Small Interfering RNA (siRNA)IBA 01/2016 - 08/2010
2	nutlin 3IBA 09/2014 - 08/2012
2	indoleIBA 08/2012 - 08/2008
2	SmokeIBA 03/2012 - 05/2006
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 12/2011 - 01/2010
2	Histones (Histone)IBA 09/2010 - 08/2006
2	CytosineIBA 07/2010 - 07/2004
2	Glycogen Synthase KinasesIBA 01/2010 - 03/2008
2	ErbB Receptors (EGF Receptor)IBA 09/2009 - 01/2008
2	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 07/2009 - 03/2008
2	Histidine (L-Histidine)FDA Link 11/2007 - 08/2006
2	Cyclin-Dependent Kinase Inhibitor p16IBA 02/2007 - 04/2002
2	Tumor Suppressor Protein p14ARF (p14ARF)IBA 01/2005 - 07/2004
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2004 - 03/2004
2	Capsules (Microcapsules)IBA 03/2004 - 03/2004
1	ChemokinesIBA 05/2022
1	Growth Differentiation Factor 15IBA 05/2022
1	LigandsIBA 05/2022
1	AntibodiesIBA 01/2022
1	AlbuminsIBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	Carboxypeptidase H (Carboxypeptidase E)IBA 01/2022
1	Transferrin (beta 2 Transferrin)IBA 01/2022
1	Prealbumin (Transthyretin)IBA 01/2022
1	Dendrimers (Dendrons)IBA 01/2021
1	IronIBA 01/2021
1	PhosphoproteinsIBA 06/2020
1	Glucose (Dextrose)FDA LinkGeneric 06/2020
1	PhosphopeptidesIBA 06/2020
1	Interleukin-33IBA 01/2020
1	adducinIBA 10/2019
1	Cyclin D1IBA 10/2019
1	Long Noncoding RNAIBA 01/2019
1	histone deacetylase 3IBA 01/2019

Therapy/Procedure

13	Therapeutics 01/2021 - 01/2011
4	Drug Therapy (Chemotherapy) 01/2012 - 01/2007
3	Immunotherapy 01/2022 - 01/2020
2	Intraperitoneal Injections 01/2013 - 01/2012
1	Medical Day Care (Partial Hospitalization) 04/2022
1	Activities of Daily Living (ADL) 03/2022
1	Quantum Dots (Quantum Dot) 01/2021